What Is Percocet?

    Percocet (oxycodone and acetaminophen) is a combination drug consisting of an opioid and a pain reliever and fever reducer (analgesic and antipyretic) used for the management of moderate to severe pain, usually for an extended time period. Percocet is available in generic form.

    What Are Side Effects of Percocet?

    • constipation,
    • nausea,
    • vomiting,
    • upset stomach,
    • sleepiness,
    • drowsiness,
    • dizziness,
    • lightheadedness,
    • itching,
    • headache,
    • blurred vision,
    • dry mouth,
    • sweating, and
    • decreases in the ability to feel pain.

    Tell your doctor if you experience serious side effects of Percocet including:

    • respiratory depression,
    • apnea (periodic stoppage of breathing),
    • respiratory arrest,
    • circulatory depression,
    • low blood pressure (hypotension),
    • shock, and
    • death.

    Dosage for Percocet

    Percocet is available as tablets in strengths of 2.5/325, 5/325, 7.5/325, 7.5/500, 10/325, and 10/650 mg tablets (oxycodone/acetaminophen strengths), with a total daily dose not to exceed 4 grams of acetaminophen to avoid liver damage; 60 mg total per day of oxycodone strength and above used only for opioid tolerant patients. The tablets should be swallowed whole because broken or chewed tablets release oxycodone too rapidly and because it is rapidly adsorbed, too concentrated levels will be present in the body which can lead to death.

    What Drugs, Substances, or Supplements Interact with Percocet?

    Percocet may interact with other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, other medicines that can make you sleepy or slow your breathing, glycopyrrolate, mepenzolate, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bladder or urinary medications, bronchodilators, or irritable bowel medications. Tell your doctor all medications and supplements you use.

    Percocet During Pregnancy and Breastfeeding

    Safety has not been established in children; caution or avoidance is suggested in pregnant and breastfeeding women as infants can be born with opioid tolerance and depressed respirations. In addition, low concentrations of Percocet have been found in breast milk. Patients with liver damage or who drink large amounts of alcohol may be at increased risk of liver damage due to the acetaminophen component in this combination drug. This opioid is often a drug of choice for addictive use and can easily lead to dependency. Some patients may develop tolerance for the drug and need to be slowly weaned off the drug.

    Additional Information

    Our Percocet Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

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